CNLD Seminar with Alessandro Leronni

Abstract: Cytoskeletal mechanics is crucial in developmental

biology, influencing morphogenesis, growth, and

differentiation. While membrane potential fluctuates

during the cell cycle, its role in regulating cytoskeletal

mechanics remains an open area of investigation. This

talk presents a continuum multi-physics model that

captures the interplay between mechanics and

bioelectricity within a cell cluster, incorporating

membrane potential dynamics, ion transport, fluid flow,

and passive cytoskeletal behaviour. Using finite element

analysis on a 1D benchmark, the model explores how

ion channels, gap junctions, aquaporins, and tight

junctions affect the mechanics of the cluster. Future

extensions include bioelectrical activation of cytoskeletal

contractility and tissue growth, with implications for

regenerative medicine, cancer therapy, and

bioelectronics.